Tim Liu presented the NaviFUS device (also referred to as NAviFUS-001). NaviFUS uses a novel neuronavigation technique to help simulate the optimal opening of the BBB near a tumor. The neuronavigator uses optical tracking to visualize the position of a surgical instrument by recognizing fiducial markers (registration), which are custom NaviFUS markers.
The standard treatment workflow includes pre-treatment MR imaging to confirm the tumor and select target location, CT scan, personalized treatment plan, and skull penetration estimation that is integrated into the neuronavigator. The procedure takes 30 minutes and consists of 4 steps:
1. setting up the neuronavigation guidance,
2. IV microbubble injection,
3. FUS sonication, and
4. post-treatment MR imaging.