NaviFUS Presents Promising Stroke Rehabilitation Data at AOCCN 2025
Taipei, Taiwan – November 25, 2025 – At the 8th Asian–Oceanian Congress of Clinical Neurophysiology (AOCCN 2025) in Taipei, NaviFUS Corp. (6872) announced encouraging early clinical data showing that its neuronavigation-guided focused ultrasound (FUS) system is expanding beyond epilepsy into the field of stroke rehabilitation.
Over the past two years, NaviFUS has been collaborating with Chang Gung Memorial Hospital, National Taiwan University Hospital (NTUH), and Taipei Veterans General Hospital to explore multiple neuromodulation indications, including Parkinson’s disease, essential tremor, and stroke rehabilitation. These early academic studies have consistently demonstrated favorable safety and therapeutic potential.
Professor Hao-Li Liu, founder of NaviFUS and faculty member in the Department of Electrical Engineering at National Taiwan University, noted that the latest stroke rehabilitation results presented by the NTUH Department of Physical Medicine and Rehabilitation show how NaviFUS can help overcome key limitations of conventional rehabilitation. The data suggest a safer and more effective option for stroke survivors and their physicians.
In the early-stage study led by Dr. Ming-Yen Hsiao’s team at NTUH, subacute stroke patients (within three months of onset) received NaviFUS treatments on five consecutive days in addition to standard rehabilitation. The results demonstrated strong clinical value in three major areas:
1. Stronger motor recovery and Best-in-Class potential
Patients in the NaviFUS group achieved significantly greater functional gains than those receiving standard care alone. When compared with a matched cohort treated with conventional transcranial magnetic stimulation (TMS), the NaviFUS group showed clearly superior improvement in the Fugl-Meyer Assessment (FMA) for upper-limb motor function, indicating more efficient recovery.
2. High safety with preserved cognition
Intensive safety monitoring revealed no major adverse events during treatment. Brain CT scans showed no new hemorrhage or microbleeds. Cognitive function, measured by the Mini-Mental State Examination (MMSE), remained stable or slightly improved, easing concerns about potential damage to vulnerable brain tissue.
3. Activation of brain repair and real-world benefits
Physiological data showed significantly increased bilateral cortical excitability after treatment, suggesting that NaviFUS can “wake up” damaged neural networks and enhance neuroplasticity. This was accompanied by sustained improvement trends in the Stroke Impact Scale (SIS), the Barthel Index for activities of daily living, and the Wolf Motor Function Test (WMFT), reflecting meaningful gains in real-world function.
With global population aging, stroke has become a leading cause of long-term disability. Traditional physical and occupational therapy is time-consuming, labor-intensive, and highly dependent on patients’ physical condition and motivation. Many patients experience a recovery plateau beyond the first three months—the so-called golden window—making it difficult to further improve independence in daily life.
Market research firms Fact.MR and Allied Market Research estimate that the global stroke management and rehabilitation market will approach USD 60–70 billion around 2030–2032, underscoring both the scale of the challenge and the need for innovation. There is strong demand for a non-invasive therapy that can actively stimulate injured brain regions, shorten rehabilitation time, and help patients regain function more efficiently. NaviFUS aims to meet this unmet need with its precision navigation-guided focused ultrasound platform.
Arthur Lung, General Manager of NaviFUS Corp., commented that the AOCCN 2025 presentation further strengthens NaviFUS’s competitive edge in stroke rehabilitation. Compared with traditional rehabilitation, which is often passive and prolonged, the NaviFUS system offers an active, targeted, and safe brain-repair solution. As clinical evidence continues to build, the company plans to accelerate regulatory pathways and international partnerships to drive future commercialization.
Looking ahead, NaviFUS expects this breakthrough in stroke rehabilitation to become a new growth engine for the company and, more importantly, to help stroke survivors around the world regain independence and improve quality of life.
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